RESUMO
Porous structure design and the content regulation of heteroelements have been proved to be effective strategies to boost photocatalytic H2 generation activity of graphitic carbon nitride (g-C3N4) based photocatalyst. Herein, a series of porous graphitic carbon nitride with high concentration of oxygen (g-C3N4-O) photocatalysts were synthesized via in situ polymerization process using colloidal SiO2 as oxygen source. The content of oxygen within the g-C3N4-O photocatalysts could be tuned by adjusting the amount of added colloidal SiO2 during the preparation procedure. The introduced oxygen replaced two-coordinated nitrogen atom, influencing band edge position and localized electron distribution, thereby enhancing visible light harvesting and photoelectric conversion. As a result, the g-C3N4-O photocatalyst with an optimal oxygen content (8.39 wt%) showed 10.5 fold enhancement in H2 evolution rate compared to that of bulk g-C3N4, attributed to the porous structure and high concentration of incorporated oxygen.
RESUMO
In the title compound, C(19)H(13)N(5)·C(4)H(8)O(2)·2H(2)O, the mol-ecular skeleton of the 2,6-bis-(benzimidazol-2-yl)pyridine (bbip) mol-ecule is essentially planar (r.m.s. deviation = 0.023â Å). An extensive three-dimensional network of inter-molecular N-Hâ¯O, O-Hâ¯O and O-Hâ¯N hydrogen bonds consolidates the crystal packing, which also exhibits π-π inter-actions between the five- and six-membered rings from neighbouring bbip mol-ecules.
RESUMO
The asymmetric unit of the title hydrated co-crystal, 2C19H13N5·C6H10O4·4H2O, consists of one 2,6-bis-(1H-benzimidazol-2-yl)pyridine mol-ecule, half of an adipic acid mol-ecule (bis-ected by an inversion center) and two water solvates. In the crystal, N-Hâ¯O, O-Hâ¯O and O-Hâ¯N hydrogen bonds and π-π inter-actions [centroid-centroid distances = 3.769â (2) and 3.731â (2)â Å] form a three-dimensional supra-molecular structure.
RESUMO
The crystal structure of the title co-crystal, C(12)H(9)N(3)·C(5)H(8)O(4), N-Hâ¯O and O-Hâ¯N hydrogen bonds link the components. There are also π-π stacking inter-actions between the imidazole rings, between the imidazole and pyridine rings and between the pyridine and benzene rings [centroid-centroid distances = 3.643â (2), 3.573â (2) and 3.740â (1)Å, respectively].
RESUMO
In the title compound, C(21)H(18)N(2)O, the dihedral angle between the phenol ring and the carbazole system is 39.34â (2)°. Inter-molecular O-Hâ¯N hydrogen bonds and C-Hâ¯π and π-π inter-actions [centroid-centroid distances = 3.426â (2) and 3.768â (2)â Å] stabilize the crystal structure.
RESUMO
NFATc1 is an important transcription factor which is critical for lineage selection in T-cell differentiation, cardiac valve morphogenesis, lymphatic endothelial development, osteoblast differentiation and osteoclastogenesis. Especially, it is a master regulator of RANKL-induced osteoclast differentiation and plays a pivotal role in osteoclast fusion and osteoclast activation via up-regulation of various genes responsible for osteoclast adhesion, migration, acidification, degradation of inorganic and organic bone matrix. In the present review, some of the known features of NFATc1 such as structure, function and its roles in physiological or pathophysiological processes are highlighted.
Assuntos
Fatores de Transcrição NFATC/fisiologia , Osteoclastos/fisiologia , Animais , Reabsorção Óssea/tratamento farmacológico , Reabsorção Óssea/genética , Reabsorção Óssea/fisiopatologia , Sinalização do Cálcio , Adesão Celular/genética , Diferenciação Celular/efeitos dos fármacos , Fusão Celular , Movimento Celular/genética , Humanos , Fatores de Transcrição NFATC/antagonistas & inibidores , Fatores de Transcrição NFATC/química , Fatores de Transcrição NFATC/genética , Osteoclastos/citologia , Osteoclastos/efeitos dos fármacos , Ligante RANK/metabolismo , Receptor Ativador de Fator Nuclear kappa-B/metabolismo , Regulação para CimaRESUMO
CLC-7 is a member of the voltage-gated chloride channels family. It resides mainly in the late endosomes, lysosomes and the ruffled membrane of osteoclasts. Mice deficient in the ubiquitously expressed ClC-7 Cl(-) channel show severe osteopetrosis and retinal degeneration. In the present review, some of the known features of CLC-7 such as structure, function and its roles in physiological or pathophysiological processes are highlighted.
Assuntos
Canais de Cloreto/antagonistas & inibidores , Canais de Cloreto/metabolismo , Doenças Neurodegenerativas/tratamento farmacológico , Osteopetrose/tratamento farmacológico , Degeneração Retiniana/tratamento farmacológico , Animais , Canais de Cloreto/genética , Humanos , Camundongos , Doenças Neurodegenerativas/genética , Doenças Neurodegenerativas/metabolismo , Osteopetrose/genética , Osteopetrose/metabolismo , Degeneração Retiniana/genética , Degeneração Retiniana/metabolismoRESUMO
In the title mol-ecule, C(16)H(16)N(2)O, the pyridine ring and non-H atoms of the =CH-C(=O)- unit are coplaner, the largest deviation being 0.045â (2)â Å for the O atom. The dihedral angle between this plane and the benzene ring is 2.79â (2)°. The mol-ecular structure is stabilized by inter-molecular C-Hâ¯π and inter-actions.
RESUMO
The Cu(II) ion in the title complex, [Cu(C(15)H(12)N(2)O(3))(C(4)H(9)NO)], is coordinated by one carbonyl O atom, one hydrazine N atom and one phenolate O atom from the doubly deprotonated tridentate ligand and one N atom from a morpholine mol-ecule, forming a distorted trans-CuN(2)O(2) square-planar coordination geometry. An intra-molecular O-Hâ¯N hydrogen bond occurs within the ligand, generating an S(6) ring.